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GNP 8

Q.  Name as many brain diseases as you can that cause intranuclear inclusions. 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

A.  Viral diseases are the most common diseases to cause intranuclear inclusions.  This includes:

*herpes virus (Pseudorabies, Aujeszy’s disease, Canine herpes virus encephalitis, equine herpes virus 1, bovine herpes encephalitis)

*Borna virus (AKA “staggering disease” found in horses, sheep and cats) has primarily intranuclear inclusions and rarely cytoplasmic inclusions.  The inclusions are called “Joest-Degen” bodies.

*Adenoviruses (contagious hepatitis in dogs)

*Paramyxovirus can be intranuclear or intracytoplasmic (canine distemper virus)

 

Rarely metabolic or degenerative diseases can cause intranuclear inclusions. 

 

Veterinary Neuropathology: essentials of theory and practice.  Vandervelde et al.  Wiley-Blackwell 2012.  Pp 54-63.